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Behind the science


​​Herbalife​ 19 October 2023

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Epicor®, clinically shown to support your immune system

Unlike any other vitamin supplements or ingredients, EpiCor® is a whole food supplement ingredient, clinically shown to support a strong immune system. When EpiCor® is taken daily, it helps people live a healthier lifestyle by supporting immune health, nasal comfort and can also support the gut microbiome.

Key benefits

Immune balance

Overall, six published human clinical studies together show that EpiCor® supports immune balance. This includes two published human clinical trials in the winter, one published human clinical trial in the spring and two other published human clinical trials on immune modulators help show the immune balancing effects of EpiCor®.

Gut microbiome support

One published randomized, double-blind placebo controlled human clinical trial with 80 subjects over a 6-week period was done to show that EpiCor® may positively modulate the gut microbiota. Two published digestive model trials also have been done to show that EpiCor® supports the gut microbiome.

Spring immune support

One published randomized, double-blind placebo controlled human clinical trial with 96 subjects over a 12-week period was done to show that EpiCor® supports immune health and nasal comfort in the spring.

Winter immune support

Two published randomized, double-blind placebo-controlled human clinicals trials with 116 subjects over a 12-week period was done to show that EpiCor® supports immune health during winter challenges.

Clinically researched

Not all research is created equal. The EpiCor® brand is built upon over 75 years of science and research in our health and wellness technology. We’re absolutely committed to meeting or exceeding governmental and industry standards for safety and performance. Studies on EpiCor® include: seven published preclinical studies and eight published human clinical trials (1-15).

What is Epicor®?

EpiCor® is the world’s leading whole food fermentate ingredient. EpiCor® whole food fermentate is a postbiotic ingredient made using natural yeast (“Saccharomyces cerevisiae” – AKA brewers’ or bakers’ yeast) that goes through a closely held trade secret fermentation and drying process. Over a dozen published studies show EpiCor® fermentate helps to deliver immune health and gut health benefits. When taken daily, EpiCor® has been shown to be a safe way to help people live more healthy days. EpiCor® is Kosher, gluten free, Non-GMO Project Verified, BSE & TSE free and is a vegan immune health supplement ingredient.


Q1: What makes EpiCor® different from other immune ingredients?

EpiCor® is a one-of-a-kind clinically tested whole food fermentate with 15 published studies. Human clinical and preclinical trials show that EpiCor® supports immune health and the gut microbiome.

Q2: Should EpiCor® be taken all year round?

Our immune systems are constantly being challenged every day, not just during specific times of the year. EpiCor® is a safe and natural way to support daily immune and GI health.

Q3: Should EpiCor® be taken with meals or between meals?

EpiCor® is not known to upset your stomach like some ingredients. EpiCor® can be taken with or without a meal, during any time of the day, and in multiple doses. For our human clinical studies, subjects took EpiCor® first thing in the morning.

Q4: Does EpiCor® contain any wheat, gluten, barley, rye or oats?

EpiCor® does not contain wheat gluten, barley, rye, or oats.

Q5: Does EpiCor® contain yeast?

One of the starting ingredients in EpiCor® is baker’s yeast, so after the fermentation process EpiCor® does contain some beneficial inactive yeast. Like other fermented products such as beer, wine, bread or yogurt, the end product is very different from the starting ingredients.

Q6: Does EpiCor® have any side effects?

EpiCor® has been thoroughly tested for safety. In all of the tests and studies, there has not been a case of adverse side effects. As is the case for all dietary supplements, you should talk with your healthcare practitioner about how any dietary supplement may affect your health.

List of published research

  1. Schauss, A. G.; Vodjani, A., Discovery of edible fermentation product with unusual immune enhancing properties in humans. FASEB J 2006, 20 (4), A143. [Online reference: https://www.fasebj.org/doi/abs/10.1096/fasebj.20.4.A143-c]
  2. Jensen, G. S.,  et al. An anti-inflammatory immunogen from yeast culture induces activation and alters chemokine receptor expression on human natural killer cells and B lymphocytes in vitro. Nutrition Research 2007, 27, 327-335. [Online reference: https://www.researchgate.net/publication/257104459]
  3. Moyad, M. A.,  et al. Effects of a modified yeast supplement on cold/flu symptoms. Urol Nurs 2008, 28 (1), 50-5. [Online reference: http://www.ncbi.nlm.nih.gov/pubmed/18335698]
  4. Jensen, G. S.,  et al. A double-blind placebo-controlled, randomized pilot study: consumption of a high-metabolite immunogen from yeast culture has beneficial effects on erythrocyte health and mucosal immune protection in healthy subjects.  Open Nutr J 2008, 2, 68-75. [Online reference: https://www.embriahealth.com/media/cms/The_Open_Nutrition_Journal_F930A1A39680D.pdf]
  5. Honzel, D,  et al. Comparison of chemical and cell-based antioxidant methods for evaluation of foods and natural products: generating multifaceted data by parallel testing using erythrocytes and polymorphonuclear cells. J Agric Food Chem 2008, 56 (18), 8319-25. [Online reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498863]
  6. Moyad, M. A., et al. Immunogenic yeast-based fermentation product reduces allergic rhinitis-induced nasal congestion: a randomized, double-blind, placebo-controlled trial. Adv Ther 2009, 26 (8), 795-804. [Online reference: https://www.ncbi.nlm.nih.gov/pubmed/19672568]
  7. Moyad, M. A., et all.  Immunogenic yeast-based fermentate for cold/flu-like symptoms in nonvaccinated individuals. J Altern Complement Med 2010, 16 (2), 213-8. [Online reference: https://www.ncbi.nlm.nih.gov/pubmed/19672568]
  8. Jensen, G. S., et al.  Antioxidant bioavailability and rapid immune-modulating effects after consumption of a single acute dose of a high-metabolite yeast immunogen: results of a placebo-controlled double-blinded crossover pilot study. J Med Food 2010, 14, 1002–1010. [Online reference: https://www.ncbi.nlm.nih.gov/pubmed/19672568]
  9. Evans, M., et all.  A dried yeast fermentate prevents and reduces inflammation in two separate experimental immune models. Evid Based Complement Alternat Med 2012, 2012, 7. [Online reference: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328167]
  10. Possemiers, S., et al.  A dried yeast fermentate selectively modulates both the luminal and mucosal gut microbiota and protects against inflammation, as studied in an integrated in vitro approach. J Agric Food Chem 2013, 61 (39), 9380-9392. [Online reference: http://www.ncbi.nlm.nih.gov/pubmed/24006902]
  11. Marzorati, M., et al.  The HMI module: a new tool to study the Host-Microbiota Interaction in the human gastrointestinal tract in vitro. BMC Microbiol 2014, 14 (1), 133. [Online reference: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039060/]
  12. Jensen, G. S., et all.  Anti-inflammatory properties of a dried fermentate in vitro and in vivo. J Med Food 2014, 18(3), 378-84. [Online reference: http://www.ncbi.nlm.nih.gov/pubmed/25105458]
  13. Durcray, H.A.G., et al.  Mitigation of heat stress-related complications by a yeast fermentate product. Jl  Therm Bio 2016, 60,26–32. [Online reference: https://www.ncbi.nlm.nih.gov/pubmed/27503713]
  14. Pinheiro, I., et al. .A yeast fermentate improves gastrointestinal discomfort and constipation by modulation of the gut microbiome: results from a randomized double-blind placebo-controlled pilot trial. BMC Complement Altern Med 2017, 17 (1), 441. [Online reference:  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584023/]

  15. Ducray, H.A.G., et al.  Yeast fermentate prebiotic improves intestinal barrier integrity during heat stress by modulation of the gut microbiota in rats.  J  Appl Microbiol 2019, 127, 1192—1206. [Online reference: https://www.ncbi.nlm.nih.gov/pubmed/31230390]